| Year | Detail |
| 1978 |
Promega was founded as Biotec by Bill Linton |
| 1981 |
RNasin is introduced |
| 1983 |
Biotec becomes Promega Biotec & Riboprobe System launched |
| 1985 |
pGEM Cloning Vectors created |
| 1988 |
Taq DNA Polymerase is introduced |
| 1989 |
Promega opened its Research and Development Center in Madison |
| 1994 |
First luciferase patent granted |
| 1995 |
Promega opens in Japan |
| 1997 |
First Profiles in DNA published |
| 2002 |
Protein production facility opens in Madison |
| 2006 |
Trypsin Gold launched |
| 2012 |
Nanoluc luciferase technology launched |
| 2013 |
Feynman Center, state-of-the-art cGMP manufacturing facility, opens in Madison |
| 2015 |
Kepler Center, Promega global processing center opens |