| Year | Detail |
| 1961 |
TOA Electric Co. Ltd. (presently TOA Corp.) entered the medical electronics market. |
| 1966 |
Launched the CC-1002 automated hematology analyzer. |
| 1968 |
Established TOA Medical Electronics Co. Ltd. (presently Sysmex Corp). |
| 1972 |
Acquired the Medical Electronics (ME) Equipment Division of TOA Electric Co. Ltd. |
| 1973 |
Established the Kakogawa Factory in Kakogawa. |
| 1978 |
Launched the corporate brand name "Sysmex." |
| 1979 |
Established a U.S. subsidiary TOA Medical Electronics (USA) Inc. (presently Sysmex America Inc.) |
| 1986 |
Established the new Kobe Factory and relocated headquarters to Kobe. |
| 1988 |
Launched the NE-8000 automated hematology analyzer. |
| 1991 |
Established the Ono Factory (presently Sysmex International Reagents Co. Ltd. Ono Factory) in Ono. |
| 1992 |
Established Sysmex TMC Co. Ltd. |
| 1995 |
Established the joint venture Jinan Dongya Medical Electronics Co. Ltd. (presently Jinan Sysmex Medical Electronics Co. Ltd.) in China. |
| 1998 |
Established the joint venture Sysmex Transasia Bio-Medicals Private Ltd. (presently Sysmex India Pvt. Ltd.) |
| 2000 |
Established the Chinese subsidiary Sysmex Shanghai Ltd. in Shanghai. |
| 2001 |
Launched the PAMIA-40i immunoagglutination analyzer. |
| 2001 |
Acquired Delphic Medical Systems and changed its name to Sysmex Delphic Limited. |
| 2003 |
Merged two U.S. subsidiaries Sysmex Corporation of America and Sysmex Infosystems America Inc. to establish Sysmex America Inc. |
| 2009 |
Established the Indian joint venture Sysmex Transasia Services Pvt Ltd. |
| 2011 |
Acquired Katakura Industries Co. Ltd.'s Research Institute of Biological Science. |
| 2016 |
Converted Riken Genesis Co. Ltd. to a subsidiary. |
| 2022 |
Astrego Diagnostics AB becomes wholly owned Sysmex subsidiary. |
| 2023 |
Sysmex announced global business partnership agreement with Roche Diagnostics International Ltd. |
| 2024 |
Sysmex and Hitachi High-Tech agree to collaborate on development of new genetic testing systems. |